Back to Search
Start Over
Potassium and the use of renin-angiotensin-aldosterone system inhibitors in heart failure with reduced ejection fraction: data from BIOSTAT-CHF
- Source :
- European journal of heart failure, 20, 923-930. Wiley-Blackwell, European Journal of Heart Failure, 20(5), 923-930. Wiley
- Publication Year :
- 2018
-
Abstract
- Background Hyperkalaemia is a common co-morbidity in patients with heart failure with reduced ejection fraction (HFrEF). Whether it affects the use of renin-angiotensin-aldosterone system inhibitors and thereby negatively impacts outcome is unknown. Therefore, we investigated the association between potassium and uptitration of angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) and its association with outcome. Methods and results Out of 2516 patients from the BIOSTAT-CHF study, potassium levels were available in 1666 patients with HFrEF. These patients were sub-optimally treated with ACEi/ARB or beta-blockers and were anticipated and encouraged to be uptitrated. Potassium levels were available at inclusion and at 9 months. Outcome was a composite of all-cause mortality and heart failure hospitalization at 2 years. Patients' mean age was 67 +/- 12 years and 77% were male. At baseline, median serum potassium was 4.3 (interquartile range 3.9-4.6) mEq/L. After 9 months, 401 (24.1%) patients were successfully uptitrated with ACEi/ARB. During this period, mean serum potassium increased by 0.16 +/- 0.66 mEq/L (P 0.5 for all). Conclusion Higher potassium levels are an independent predictor of enduring lower dosages of ACEi/ARB. Higher potassium levels do not attenuate the beneficial effects of ACEi/ARB uptitration.
- Subjects :
- CHRONIC KIDNEY-DISEASE
ACE-INHIBITORS
Guideline-directed medication
Heart failure
Hyperkalaemia
Outcome
Renin-angiotensin-aldosterone system inhibitors
ASSOCIATION
WORSENING RENAL-FUNCTION
EMPHASIS-HF
HYPERKALEMIA
EUROPEAN-SOCIETY
MILD PATIENTS HOSPITALIZATION
SERUM POTASSIUM
MINERALOCORTICOID RECEPTOR ANTAGONIST
cardiovascular diseases
Subjects
Details
- Language :
- English
- ISSN :
- 13889842
- Database :
- OpenAIRE
- Journal :
- European journal of heart failure, 20, 923-930. Wiley-Blackwell, European Journal of Heart Failure, 20(5), 923-930. Wiley
- Accession number :
- edsair.dedup.wf.001..5d14151b5fb2326b5fd3b9352e6c2db1