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Longitudinal MRI structural findings observed in accelerated knee osteoarthritis: data from the Osteoarthritis Initiative
- Source :
- Skeletal radiology, vol 48, iss 12
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- ObjectiveTo analyze structural, longitudinal MRI findings during the development of accelerated knee osteoarthritis (AKOA) over 4years.Materials and methodsFrom the Osteoarthritis Initiative (OAI), knees with no radiographic osteoarthritis (KL 0/1) developing advanced-stage osteoarthritis (KL 3/4; AKOA) within a 4-year (y) timeframe were selected. MRIs were graded using the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) at the beginning of the 4-year timeframe (index visit), at 2-year, and 4-year follow-up. Morphological and clinical findings associated with KL 3/4 onset within 2years compared to 4years were assessed using generalized estimating equations.ResultsAKOA was found in 162 knees of 149 subjects (age 63.25 ± 8.3; 103 females; BMI 29.4 ± 3.9). Moderate to severe meniscal lesions WORMS ≥3 were present in 25% (41/162) at the index visit, 64% (104/162) at 2-year and 93% (151/162) at 4-year follow-up. Meniscal extrusion was the most prevalent finding (ranging from 18% at the index visit, 45% at 2-year and 94% at 4-year follow-up) and root tears were the most common types of tears (9% at the index visit; 22% at 2years and 38% at 4years). Risk factors associated with KL 3/4 onset within 2years included root tears at the index visit (adjusted OR, 2.82; 95% CI: 1.33, 6.00; p = 0.007) and incident knee injury (42%, 49/116 vs. 24%, 11/46, p = 0.032).ConclusionsMeniscal abnormalities, in particular extrusion and root tears, were the most prevalent morphological features found in subjects with AKOA. These results suggest that meniscal abnormalities have a significant role in accelerated progression of OA.
- Subjects :
- Male
Prevention
Arthritis
Pain Research
Clinical Sciences
Reproducibility of Results
Middle Aged
Magnetic Resonance Imaging
Arthroscopy
Nuclear Medicine & Medical Imaging
Cartilage
Risk Factors
Osteoarthritis
Disease Progression
Humans
2.1 Biological and endogenous factors
Knee
Female
Longitudinal Studies
Chronic Pain
Aetiology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Skeletal radiology, vol 48, iss 12
- Accession number :
- edsair.dedup.wf.001..64180879af398200f4bb87d030f770f0