A single amino acid change A19V in perforin: a novel, frequent predisposing factor to childhood acute lymphoblastic leukemia?

Authors :: Santoro, A.
TRIZZINO A, C.
LO NIGRO, L.
Corsello, G.
Arico, M.
SANTORO A
CANNELLA S TRIZZINO A
LO NIGRO L
CORSELLO G
ARICO M
Publication Year :: 2005
Abstract: We screened 100 children with acute lymphoblastic leukemia (ALL) to assess the incidence of single amino acid change A91V in perform. Heterozygous A91V was found in 12/100 patients and 5/127 controls (OR, 3.4; 95%CI: 1.15-9.95; p=0.014). A91V is a novel and frequent predisposing factor for childhood ALL.

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