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A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway
- Source :
- mBio, vol 2, iss 6
- Publication Year :
- 2011
- Publisher :
- eScholarship, University of California, 2011.
-
Abstract
- The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown mechanisms. Here we show that bacterial delivery or ectopic expression of SipA, a T3SS-1-translocated protein, led to the activation of the NOD1/NOD2 signaling pathway and consequent RIP2-mediated induction of NF-κB-dependent inflammatory responses. SipA-mediated activation of NOD1/NOD2 signaling was independent of bacterial invasion in vitro but required an intact T3SS-1. In the mouse colitis model, SipA triggered mucosal inflammation in wild-type mice but not in NOD1/NOD2-deficient mice. These findings implicate SipA-driven activation of the NOD1/NOD2 signaling pathway as a mechanism by which the T3SS-1 induces inflammatory responses in vitro and in vivo.
- Subjects :
- Salmonella typhimurium
Virulence Factors
Nod2 Signaling Adaptor Protein
Inbred C57BL
Autoimmune Disease
Microbiology
Cell Line
Vaccine Related
Mice
Bacterial Proteins
Biodefense
Nod1 Signaling Adaptor Protein
2.1 Biological and endogenous factors
Animals
Humans
Aetiology
Prevention
Inflammatory and immune system
Microfilament Proteins
NF-kappa B
Foodborne Illness
digestive system diseases
body regions
Infectious Diseases
Emerging Infectious Diseases
Salmonella Infections
bacteria
Digestive Diseases
Signal Transduction
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- mBio, vol 2, iss 6
- Accession number :
- edsair.dedup.wf.001..72545796eb01ee40c0132dbb154dec99