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Celiac disease associated with autoimmune hepatitis and autoimmune hyperthyroidism
- Source :
- Medicinski Glasnik, Volume 10, Issue 2
- Publication Year :
- 2013
-
Abstract
- Although celiac disease (CD) may occur in patients with other immune-mediated disorders, its coexistence with multiple autoimmune diseases is not frequently described. We report the case of a 23-year-old woman referred to our centre because of jaundice and diarrhoea, who was diagnosed with CD in childhood. She complied with a gluten-free diet until puberty. Laboratory tests and liver biopsy were performed to establish the diagnosis of autoimmune hepatitis. Her thyroid- specific peroxides levels and thyroid gland function tests were altered as well, indicating the presence of an autoimmune disorder of the thyroid gland. Immunosuppressive treatment led to normalization of transaminases levels and bilirubin. In conclusion, other autoimmune diseases should be ruled out in patients with CD.<br />Iako celijakija ili glutenska enteropatija može biti udružena s drugim imunološkim bolestima, udruženost celijakije s više autoimunih bolesti nije česta. U ovom radu prikazujemo slučaj 23- godišnje bolesnice, liječene u našem Centru zbog ikterusa i proljeva, a kojoj je dijagnoza celijakije postavljena još u djetinjstvu. Do početka puberteta pacijentica se pridržavala bezglutenske dijete. Tijekom boravka u našem Centru, učinjenom dijagnostičkom obradom (laboratorijski pokazatelji i patohistološki nalaz bioptata jetre), dokazan je autoimuni hepatitis. Nadalje, funkcionalni testovi štitnjače, kao i pozitivan nalaz antitijela na tkivnu peroksidazu, ukazivali su na autoimunu bolest štitnjače. Primjenom imunosupresivne terapije došlo je do normalizacije vrijednosti aminotransferaza, kao i regresije ikterusa. Slijedom navedenog, u bolesnika s celijakijom nužno je razmišljati i o drugim imunološkim bolestima.
- Subjects :
- BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina
multiple autoimmune diseases
celiac disease
autoimmune hepatitis
autoimmune hyperthyroidism
diet
bezglutenska, dijeta
BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine
gluten- free
imunološke bolesti
Subjects
Details
- Language :
- English
- ISSN :
- 18400132
- Database :
- OpenAIRE
- Journal :
- Medicinski Glasnik, Volume 10, Issue 2
- Accession number :
- edsair.dedup.wf.001..7298491750e2862a29f5fc98a851b66c