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The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans
- Source :
- Wells, C A, Salvage-Jones, J A, Li, X, Hitchens, K, Butcher, S, Murray, R Z, Beckhouse, A G, Lo, Y L, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, D A, Stow, J, Blanchard, H & Ashman, R B 2008, ' The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans ', Journal of Immunology, vol. 180, no. 11, pp. 7404-7413 . < http://www.jimmunol.org/content/180/11/7404.short >, The Journal of Immunology, Wells, C A, Salvage-Jones, J A, Li, X, Hitchens, K, Butcher, S, Murray, R Z, Beckhouse, A G, Lo, Y-L-S, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, D A, Stow, J, Blanchard, H & Ashman, R B 2008, ' The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans ', Journal of Immunology, vol. 180, no. 11, pp. 7404-7413 ., Scopus-Elsevier, ResearcherID
- Publication Year :
- 2008
-
Abstract
- The recognition of carbohydrate moieties by cells of the innate immune system is emerging as an essential element in antifungal immunity, but despite the number and diversity of lectins expressed by innate immune cells, few carbohydrate receptors have been characterized. Mincle, a C-type lectin, is expressed predominantly on macrophages, and is here shown to play a role in macrophage responses to the yeast Candida albicans. After exposure to the yeast in vitro, Mincle localized to the phagocytic cup, but it was not essential for phagocytosis. In the absence of Mincle, production of TNF-alpha by macrophages was reduced, both in vivo and in vitro. In addition, mice lacking Mincle showed a significantly increased susceptibility to systemic candidiasis. Thus, Mincle plays a novel and nouredundant role in the induction of inflammatory signaling in response to C. albicans infection.
- Subjects :
- Phagosomes/metabolism
Toll-Like Receptor 2/immunology
060110 Receptors and Membrane Biology
Candida albicans/immunology
Lectins, C-Type/genetics
Macrophages/immunology
INCREASES SUSCEPTIBILITY
Cell Line
Mice
Phagocytosis
Phagosomes/immunology
Macrophages/metabolism
INFECTION
REVEALS
Animals
Humans
Candida albicans/metabolism
Lectins, C-Type/immunology
Toll-Like Receptor 2/metabolism
GENE-EXPRESSION
TOLL-LIKE RECEPTORS
GALECTIN-3
Mice, Knockout
Tumor Necrosis Factor-alpha/metabolism
DECTIN-1
Mice, Inbred BALB C
IDENTIFICATION
RECOGNITION
110799 Immunology not elsewhere classified
Macrophages/cytology
Tumor Necrosis Factor-alpha/immunology
Immunity, Innate
Mice, Inbred C57BL
MURINE MACROPHAGES
Candidiasis/immunology
Disease Susceptibility
Lectins, C-Type/metabolism
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Wells, C A, Salvage-Jones, J A, Li, X, Hitchens, K, Butcher, S, Murray, R Z, Beckhouse, A G, Lo, Y L, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, D A, Stow, J, Blanchard, H & Ashman, R B 2008, ' The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans ', Journal of Immunology, vol. 180, no. 11, pp. 7404-7413 . < http://www.jimmunol.org/content/180/11/7404.short >, The Journal of Immunology, Wells, C A, Salvage-Jones, J A, Li, X, Hitchens, K, Butcher, S, Murray, R Z, Beckhouse, A G, Lo, Y-L-S, Manzanero, S, Cobbold, C, Schroder, K, Ma, B, Orr, S, Stewart, L, Lebus, D, Sobieszczuk, P, Hume, D A, Stow, J, Blanchard, H & Ashman, R B 2008, ' The macrophage-inducible C-type lectin, Mincle, is an essential component of the innate immune response to Candida albicans ', Journal of Immunology, vol. 180, no. 11, pp. 7404-7413 ., Scopus-Elsevier, ResearcherID
- Accession number :
- edsair.dedup.wf.001..7ea9e1e52e650a9340f8371b4f74cabb