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Corticosteroids and the risk of atrial fibrillation

Corticosteroids and the risk of atrial fibrillation

Authors :
van der Hooft, CS
Heeringa, J
Brusselle, GG
Hofman, A
Witteman, JCM
Kingma, JH
Sturkenboom, MCJM
Stricker, BHC
Epidemiology
Medical Informatics
Source :
Archives of Internal Medicine, 166(9), 1016-1020. American Medical Association, Archives of Internal Medicine, 166(9), 1016-1020. AMER MEDICAL ASSOC
Publication Year :
2006

Abstract

Background: High-dose ( pulse) corticosteroid therapy has been associated with the development of atrial fibrillation. This association, however, is mainly based on case reports. Methods: To test the hypothesis that high-dose corticosteroid exposure increases the risk of new-onset atrial fibrillation, we performed a nested case-control study within the Rotterdam Study, a population-based cohort study among 7983 older adults. Cases were defined as persons with incident atrial fibrillation between July 1, 1991, and January 1, 2000. Their date of diagnosis was defined as the index date. All noncases within the Rotterdam Study who were alive and eligible on this index date were used as controls. Subsequently, we compared the proportion of cases and controls that received a corticosteroid prescription within 1 month preceding the index date. Corticosteroid exposure was categorized into high-dose exposure ( oral or parenteral steroid at a daily dose >= 7.5 mg of prednisone equivalents) and low-intermediate-dose exposure (

Details

ISSN :
00039926
Database :
OpenAIRE
Journal :
Archives of Internal Medicine, 166(9), 1016-1020. American Medical Association, Archives of Internal Medicine, 166(9), 1016-1020. AMER MEDICAL ASSOC
Accession number :
edsair.dedup.wf.001..8a6ec998e2067eda039025fbbc78761b