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FIB-4 stage of liver fibrosis is associated with incident heart failure with preserved, but not reduced, ejection fraction among people with and without HIV or hepatitis C
- Source :
- Progress in cardiovascular diseases, vol 63, iss 2
- Publication Year :
- 2020
- Publisher :
- eScholarship, University of California, 2020.
-
Abstract
- BackgroundLiver fibrosis, is independently associated with incident heart failure (HF). Investigating the association between liver fibrosis and type of HF, specifically HF with reduced ejection fraction (EF; HFrEF) or HF with preserved ejection fraction (HFpEF), may provide mechanistic insight into this association. We sought to determine the association between liver fibrosis score (FIB-4) and type of HF, and to assess whether HIV or hepatitis C status modified this association.MethodsWe included patients alive on or after 4/1/2003 from the Veterans Aging Cohort Study. We followed patients without prevalent cardiovascular disease until their first HF event, death, last clinic visit, or 9/30/2015. We defined liver fibrosis as: likely advanced fibrosis (FIB-4>3.25), indeterminate (FIB-4 range 1.45-3.25), unlikely advanced fibrosis (FIB-4&nbsp
- Subjects :
- Liver Cirrhosis
Adult
Male
Ejection fraction
Time Factors
VACS Project Team
Anti-HIV Agents
Health Status
Left
Liver fibrosis
Chronic Liver Disease and Cirrhosis
Veterans Health
HIV Infections
Heart failure
Cardiorespiratory Medicine and Haematology
Cardiovascular
Severity of Illness Index
Risk Assessment
HIV Long-Term Survivors
Hepatitis
Risk Factors
Clinical Research
Humans
Ventricular Function
Incidence
Liver Disease
Cohort
HIV
Stroke Volume
Viral Load
Middle Aged
Prognosis
Hepatitis C
United States
Good Health and Well Being
Heart Disease
Cardiovascular System & Hematology
Female
Digestive Diseases
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Progress in cardiovascular diseases, vol 63, iss 2
- Accession number :
- edsair.dedup.wf.001..8a86c605a4eda2e1a4f3035ff646c9f4