Modification of the growth of MCa mammary carcinoma of CBA mouse by new adamantylpeptides

Two new adamantyl-peptides, D-(2-adamantyl)-glycyl-L-alanyl-D-isoglutamine hydrochloride (isomer 1) and L-(2-adamantyl)-glycyl-L-alanyl-D-isoglutamine hydrochloride (isomer 2) , were tested in the model of the MCa mammary carcinoma of CBA mouse. These compounds, particularly Isomer 2, showed to be more effective in reducing lung metastasis than primary tumor growth and to be active in conditions in which a low number of metastases are formed, a condition that is seen when the tumor is implanted s.c. or when its growth is slowed down by the lower inoculum size. The apparent lack of any correlation between the effect of Isomer 2 on tumor growth and metastasis formation and that of the response to Con A of the in vivo IL-2 selected spleen lymphocytes seems to suggest that the dose and treatment schedule chosen might not be the most appropriate.