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Anemia Offers Stronger Protection Than Sickle Cell Trait Against the Erythrocytic Stage of Falciparum Malaria and This Protection Is Reversed by Iron Supplementation

Authors :
Goheen, MM
Wegmüller, R
Bah, A
Darboe, B
Danso, E
Affara, M
Gardner, D
Patel, JC
Prentice, AM
Cerami, C
Source :
EBioMedicine. :123-130
Publisher :
Published by Elsevier B.V.

Abstract

BACKGROUND: Iron deficiency causes long-term adverse consequences for children and is the most common nutritional deficiency worldwide. Observational studies suggest that iron deficiency anemia protects against Plasmodium falciparum malaria and several intervention trials have indicated that iron supplementation increases malaria risk through unknown mechanism(s). This poses a major challenge for health policy. We investigated how anemia inhibits blood stage malaria infection and how iron supplementation abrogates this protection. METHODS: This observational cohort study occurred in a malaria-endemic region where sickle-cell trait is also common. We studied fresh RBCs from anemic children (135 children; age 6-24months; hemoglobin

Details

Language :
English
ISSN :
23523964 and 07210906
Database :
OpenAIRE
Journal :
EBioMedicine
Accession number :
edsair.dedup.wf.001..8e2c05a4830e18dd2d8e0f74056238a7
Full Text :
https://doi.org/10.1016/j.ebiom.2016.11.011