Association of cardiovascular emerging risk factors with acute coronary syndrome and stroke: A case-control study

"This is the pre-peer reviewed version of the following article: "Martínez Linares, J.M.; et al. Association of cardiovascular emerging risk factors with acute coronary syndrome and stroke: A case control study. Nursing and Health Sciences, 18(4): 488-495 (2016)", which has been published in final form at http://dx.doi.org/10.1111/nhs.12299 . This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
In this study, we estimated the risk of acute coronary syndrome and stroke associated with several emerging cardiovascular risk factors. This was a case-control study, where an age - and sex-matched acute coronary syndrome group and stroke group were compared with controls. Demographic and clinical data were collected through patient interviews, and blood samples were taken for analysis. In the bivariate analysis, all cardiovascular risk factors analyzed showed as predictors of acute coronary syndrome and stroke, except total cholesterol and smoking. In the multivariate logistic regression model for acute coronary syndrome, hypertension and body mass index, N-terminal section brain natriuretic peptide and pregnancy-associated plasma protein-Awere independent predictors. For stroke, the predictors were hypertension, diabetes mellitus, body mass index, and N-terminal section brain natriuretic peptide. Controlling for age, sex, and classical cardiovascular risk factors, N-terminal section brain natriuretic peptide and pregnancy-associated plasma protein-A were independent emerging cardiovascular risk factors for acute coronary syndrome, but pregnancy-associated plasma protein-A was not for stroke. High levels of cardiovascular risk factors in individuals with no episodes of cardiovascular disease requires the implementation of prevention programs, given that at least half of them are modifiable.
Health Agency of Health South of Granada.
Project from "Ministerio de Economía y Competitividad. Dirección General de Investigación Científica y Técnica". Grant Number: MTM2013-47929-P