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Severe Fatigue in the First Year Following SARS-CoV-2 Infection: A Prospective Cohort Study
- Source :
- Open forum infectious diseases, 9(5):ofac127. Oxford University Press, Open Forum Infectious Diseases, 9(5):ofac127. Oxford University Press, Verveen, A, Wynberg, E, van Willigen, H D G, Boyd, A, de Jong, M D, de Bree, G, Davidovich, U, Lok, A, Moll van Charante, E P, Knoop, H, Prins, M, Nieuwkerk, P, Agard, I, Ayal, J, Cavdar, F, Craanen, M, Deuring, A, van Dijk, A, Ersan, E, del Grande, L, Hartman, J, Koedoot, N, Leenstra, T, Lebbink, R, Loomans, D, Makowska, A, du Maine, T, de Man, I, Matser, A, van der Meij, L, van Polanen, M, Oud, M, Reid, C, Storey, L, van Wijk, M, van den Aardweg, J, van Assem, J, van Beek, M, Blankert, T, Dijkstra, M, Figaroa, O, Frenkel, L, van Gils, M, van Haga, J, Han, X, Harskamp-Holwerda, A, Hazenberg, M, Hidad, S, de Jong, N, Kootstra, N, Kuijt, L, Russell, C, van der Straten, K, van der Veen, A, Verkaik, B & Visser, G-R 2022, ' Severe Fatigue in the First Year Following SARS-CoV-2 Infection : A Prospective Cohort Study ', Open Forum Infectious Diseases, vol. 9, no. 5, ofac127 . https://doi.org/10.1093/ofid/ofac127
- Publication Year :
- 2022
-
Abstract
- Background: Severe fatigue can persist for months after coronavirus disease 2019 (COVID-19) onset. This longitudinal study describes fatigue severity and its determinants up to 12 months after illness onset across the full spectrum of COVID-19 severity. Methods: RECoVERED, a prospective cohort study in Amsterdam, the Netherlands, enrolled participants aged≥16 years after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnosis. Fatigue was measured using the validated Short Fatigue Questionnaire (SFQ; range 4-28) at months 1, 3, 6, 9, and 12 of follow-up. Fatigue severity was modeled over time using mixed-effects linear regression. Determinants of severe fatigue (SFQ≥18) at 6 months since illness onset (ie, persistent fatigue) were identified using logistic regression. Results: Between May 2020 and July 2021, 303 participants completed at least 1 fatigue questionnaire. Twelve months after illness onset, 17.4% (95% CI, 6.7% to 38.3%), 21.6% (95% CI, 11.2% to 37.7%), and 44.8% (95% CI, 28.0% to 62.9%) of participants with mild, moderate, and severe/critical COVID-19 (World Health Organization definition), respectively, experienced severe fatigue. When adjusting for age and sex, having≥3 comorbidities (P=.007), severe/critical COVID-19 (P=.002), low mood (P
- Subjects :
- predictors
COVID-19
fatigue
macromolecular substances
persistence
infection
Subjects
Details
- Language :
- English
- ISSN :
- 23288957
- Database :
- OpenAIRE
- Journal :
- Open forum infectious diseases, 9(5):ofac127. Oxford University Press, Open Forum Infectious Diseases, 9(5):ofac127. Oxford University Press, Verveen, A, Wynberg, E, van Willigen, H D G, Boyd, A, de Jong, M D, de Bree, G, Davidovich, U, Lok, A, Moll van Charante, E P, Knoop, H, Prins, M, Nieuwkerk, P, Agard, I, Ayal, J, Cavdar, F, Craanen, M, Deuring, A, van Dijk, A, Ersan, E, del Grande, L, Hartman, J, Koedoot, N, Leenstra, T, Lebbink, R, Loomans, D, Makowska, A, du Maine, T, de Man, I, Matser, A, van der Meij, L, van Polanen, M, Oud, M, Reid, C, Storey, L, van Wijk, M, van den Aardweg, J, van Assem, J, van Beek, M, Blankert, T, Dijkstra, M, Figaroa, O, Frenkel, L, van Gils, M, van Haga, J, Han, X, Harskamp-Holwerda, A, Hazenberg, M, Hidad, S, de Jong, N, Kootstra, N, Kuijt, L, Russell, C, van der Straten, K, van der Veen, A, Verkaik, B & Visser, G-R 2022, ' Severe Fatigue in the First Year Following SARS-CoV-2 Infection : A Prospective Cohort Study ', Open Forum Infectious Diseases, vol. 9, no. 5, ofac127 . https://doi.org/10.1093/ofid/ofac127
- Accession number :
- edsair.dedup.wf.001..999d57141d29a78f473a551f70fc74ab