Back to Search
Start Over
Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension
- Source :
- Dadun. Depósito Académico Digital de la Universidad de Navarra, instname
- Publication Year :
- 2009
- Publisher :
- American Heart Association, 2009.
-
Abstract
- Oxidative stress plays a critical role in the pathogenesis of hypertension. The NADPH oxidase constitutes a major source of superoxide anion in phagocytic cells, and its activation is associated with matrix metalloproteinase (MMP)-9 secretion by these cells. We investigated the effects of the angiotensin II type 1 receptor antagonist losartan and its metabolites (EXP3174 and EXP3179) on NADPH oxidase activity and MMP-9 secretion in human phagocytic cells. EXP3179, but not losartan and EXP3174, dose-dependently inhibited (P
- Subjects :
- NADPH oxidase
Hypertension
PKC
EXP3179
Metalloproteinases
Losartan
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Dadun. Depósito Académico Digital de la Universidad de Navarra, instname
- Accession number :
- edsair.dedup.wf.001..a9f23d08a0342567cb72ca5b3e8ea7e8