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The Scedosporium apiospermum species complex: seroprevalence in patients with cystic fibrosis and clinical relevance

Authors :
Durupt, Stéphane
Parize, Perrine
Nail-Billaud, Sandrine
Bienvenu, Anne-Lise
Robert, Raymond
Picot, Stéphane
Lhortolary, Olivier
Bouchara, Jean-Philippe
Durieu, Isabelle
Hospices Civils de Lyon (HCL)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon
Centre Collaborateur de l'OMS pour la Rage - Dynamique des lyssavirus et adaptation à l'hôte (CC-OMS)
Institut Pasteur [Paris] (IP)
Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP)
Université d'Angers (UA)
Hôpital de la Croix-Rousse [CHU - HCL]
Institut de Chimie et Biochimie Moléculaires et Supramoléculaires (ICBMS)
Université de Lyon-Université de Lyon-École Supérieure de Chimie Physique Électronique de Lyon (CPE)-Institut National des Sciences Appliquées de Lyon (INSA Lyon)
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS)
Institut Pasteur [Paris]
Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon)
Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Source :
Third meeting of the ECMM/ISHAM Working group "Fungal respiratory infections in Cystic Fibrosis" (Fri-CF), Third meeting of the ECMM/ISHAM Working group "Fungal respiratory infections in Cystic Fibrosis" (Fri-CF), 2014, Angers, France
Publication Year :
2014
Publisher :
HAL CCSD, 2014.

Abstract

International audience; Species of the Scedosporium apiospermum complex are emerging fungal pathogens widely recognized now as causing chronic colonization of the airways in patients with cystic fibrosis (CF). Some recent studies performed in Canada 1 and France 2 suggested that the chronic colonization of the airways by another fungal pathogen, Aspergillus fumigatus, may contribute to the progressive deterioration of the lung function observed in some patients. We studied retrospectively the seroprevalence of the S. apiospermum species complex, as a marker of close contact between patient and the fungi, in a large monocentric cohort of CF patients attended in the reference centre in Lyon, France, and evaluated the clinical parameters associated with seropositivity.RESULTS:Serum samples from 373 CF patients were analysed. Serum antibodies against the S. apiospermum species complex were detected in 35 patients (9.4% of studied population). In multivariate analysis, seropositivity to the S. apiospermum species complex was associated only with seropositivity to A. fumigatus.CONCLUSIONS:This study does not suggest an association between sensitization against the S. apiospermum species complex and poorer lung function in patients with CF. Nevertheless, prospective studies are needed to evaluate more precisely the impact of both seropositivity to this species complex and its impact on the airway colonization by these fungi and on evolution of the lung function in patients with CF and the course of the disease.

Subjects

Subjects :
[SDV]Life Sciences [q-bio]

Details

Language :
English
Database :
OpenAIRE
Journal :
Third meeting of the ECMM/ISHAM Working group "Fungal respiratory infections in Cystic Fibrosis" (Fri-CF), Third meeting of the ECMM/ISHAM Working group "Fungal respiratory infections in Cystic Fibrosis" (Fri-CF), 2014, Angers, France
Accession number :
edsair.dedup.wf.001..b70cace94db0e82adc10a709fcee0a99