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Granzyme B-secreting B cells as a potential cell therapeutic
- Source :
- FOCIS 2019, FOCIS 2019, Jun 2019, Boston, United States
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- International audience; B cells secreting granzyme B (GZMB+) with suppressive properties have been discovered in a growing number of immunological contexts, autoimmunity, chronic infection, and neoplasias, as well as in healthy volunteers under physiological conditions.To date, no phenotype has been proposed for these GZMB+ B cells, and their biology also remains uncharacterized.These data provide new insights into GZMB+ B cell biology and function that emerge as one component of a complex regulatory network. Successfully expanding these cells while maintaining their potent immunosuppressive properties provides new clues for novel future cell therapies.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- FOCIS 2019, FOCIS 2019, Jun 2019, Boston, United States
- Accession number :
- edsair.dedup.wf.001..c0c204818991738a68c9460988220e7d