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MiR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer
- Source :
- Liu, X; Bi, L; Wang, Q; Wen, M; Li, C; Ren, Y; et al.(2018). MiR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene, 37(25), 3426-3439. doi: 10.1038/s41388-018-0215-2. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/8cn713qk, Oncogene, vol 37, iss 25
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- © 2018 Macmillan Publishers Limited, part of Springer Nature. Plasmacytoma variant translocation 1 (PVT1) is an lncRNA that plays vital roles in breast cancer (BC) pathogenesis. Increasing evidence suggests that miRNAs that reside in the PVT1 locus are the main driver of the oncogenic roles of PVT1 in cancer. However, the oncogenic role and underlying mechanism of miR-1204, located in the PVT1 locus, in human cancer is still unclear. In this study, we discovered that increased expression of miR-1204 is associated with poor prognosis in BC. Moreover, miR-1204 promotes proliferation, epithelial-mesenchymal transition and invasion of BC cells both in vitro and in vivo. Mechanistic investigations demonstrated that VDR is a novel target gene of miR-1204. Interference of VDR restored miR-1204-mediated BC cell proliferation, tumorigenesis, and metastasis. Collectively, our results demonstrated that the miR-1204-VDR pathway exerts oncogenic effects in BC with potential therapeutic applications in blocking BC development and progression.
- Subjects :
- Lung Neoplasms
Epithelial-Mesenchymal Transition
Nude
Oncology and Carcinogenesis
Clinical Sciences
Breast Neoplasms
Apoptosis
Mice
Calcitriol
Cell Movement
Receptors
Cell Adhesion
Animals
Humans
Neoplasm Invasiveness
Oncology & Carcinogenesis
Inbred BALB C
Cell Proliferation
Neoplastic
Cultured
Tumor
Liver Neoplasms
Prognosis
Xenograft Model Antitumor Assays
Tumor Cells
MicroRNAs
Gene Expression Regulation
Female
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Liu, X; Bi, L; Wang, Q; Wen, M; Li, C; Ren, Y; et al.(2018). MiR-1204 targets VDR to promotes epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene, 37(25), 3426-3439. doi: 10.1038/s41388-018-0215-2. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/8cn713qk, Oncogene, vol 37, iss 25
- Accession number :
- edsair.dedup.wf.001..c0d91c85697eed68f036e6154a3f4ed9