Back to Search
Start Over
Large meta-analysis of genome-wide association studies identifies five loci for lean body mass
- Source :
- Nature communications, vol 8, iss 1
- Publication Year :
- 2017
- Publisher :
- eScholarship, University of California, 2017.
-
Abstract
- Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p
- Subjects :
- Extracellular Matrix Proteins
17-Hydroxysteroid Dehydrogenases
1.1 Normal biological development and functioning
Quantitative Trait Loci
Human Genome
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Single Nucleotide
Aldehyde Oxidoreductases
Regulatory Elements
Phenotype
Versicans
ADAMTS Proteins
Thinness
Underpinning research
Body Composition
Insulin Receptor Substrate Proteins
Genetics
Humans
Transcriptional
Polymorphism
Genome-Wide Association Study
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Nature communications, vol 8, iss 1
- Accession number :
- edsair.dedup.wf.001..c444d048c5522b1a42bea3f8cf0d1c79