Milk polar lipids reduce cardiometabolic risk factors in post-menopausal women: a randomized double-blind controlled trial

Disturbances of fasting and postprandial lipid profiles are major cardiovascular (CV) risk factors. Nutrition plays a key role in their modulation, notably in postmenopausal women at CV risk. Interest has grown on the potential benefits of milk polar lipids (MPL). However, effects of MPL supplementation in humans have been inconsistent, often due to trials being performed in healthy subjects by increasing lipid intake. We hypothesized that isolipidic enrichment of the diet with MPL via a realistic dairy product could improve lipid markers of CV risk. We notably targeted a 5-g/day dose using an originally designed butterserum microfiltration process (Gassi et al., Int. Dairy J., 2016). We performed a double-blind randomized controlled trial in 58 postmenopausal overweight women with HDL-cholesterol