Design of Leather Footwear for Diabetics Containing Chlorhexidine Digluconate Microparticles

ChlorHexidine Digluconate [CHD] was encapsulated inside an ethylcellulose shell material [Aquacoat ECD], and then spray dried to produce mixed microparticles (MPs). the validity and functional quality of the resultant [CHD-MPs] were analyzed on vamp and lining leather which are used to manufacture shoes for diabetics. the morphology, efficiency of encapsulation and in vitro release characteristics of the [CHD-MPs] were optimized in order to impregnate [CHD-MPs] onto leather footwear for diabetics. Scanning electron microscopy (SEM) was used to characterize the [CHD-MPs] and the leathers treated with it. SEM images illustrated that the [CHD-MPs] were spherical, smooth in shape and adhered well to leather. in vitro CHD-release studies from its MPs, and for leather treated with it were performed in phosphate buffer saline at pH =7.2. There was an inherently controlled release behaviour of CHD for all the formulations on leather. Finally, microbiologic studies on leather treated with [CHD-MPs] were done. This study suggested that footwear containing [CHD-MPs] is/will improve the quality of daily life for diabetics.
Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113M015]; Ege University Pharmaceutical Sciences Research Center
This work is a part of the authors' research project (No. 113M015) supported by the Scientific and Technological Research Council of Turkey (TUBITAK). the authors acknowledge Ege University Pharmaceutical Sciences Research Center (FABAL) for enabling us to use its laboratory instruments (UPLC).