Back to Search
Start Over
New therapy of pleural empyema by deoxyribonuclease
- Source :
- Brazilian Journal of Infectious Diseases v.17 n.1 2013, Brazilian Journal of Infectious Diseases, Brazilian Society of Infectious Diseases (BSID), instacron:BSID, Brazilian Journal of Infectious Diseases, Volume: 17, Issue: 1, Pages: 90-93, Published: FEB 2013
- Publication Year :
- 2013
- Publisher :
- Brazilian Society of Infectious Diseases, 2013.
-
Abstract
- Empyema is a severe complication of different diseases and traumas. Management of this complication is difficult and should comprise general and local procedures. The general procedure is mainly based on administering wide-spectrum antibiotics. Local management depends on patient general condition, but in all cases the essential procedure is to insert a drain into the pleural cavity and to evacuate the pus. Sometimes pus is very thick and its evacuation and following re-expansion of the lung is rather impossible. In these patients surgical intervention is needed. The use of intrapleural enzymes to support the drainage was first described in 1949 by Tillett and Sherry using a mixture of streptokinase and streptococcal deoxyribonuclease. Nowadays, purified streptokinase has come into widespread use, but recent studies reported no streptokinase effect on pus viscosity. On the other side, deoxyribonuclease reduces pus viscosity and may be more useful in treatment. We report two cases of intrapleural administration of Pulmozyme (alfa dornase - deoxyribonuclease (HOFFMANN-LA ROCHE AG) in dosage 2 × 2.5 mg with a significant improvement caused by changes in pus viscosity.
- Subjects :
- Viscosity
Deoxyribonuclease
bacterial infections and mycoses
Empyema
Lung
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Brazilian Journal of Infectious Diseases v.17 n.1 2013, Brazilian Journal of Infectious Diseases, Brazilian Society of Infectious Diseases (BSID), instacron:BSID, Brazilian Journal of Infectious Diseases, Volume: 17, Issue: 1, Pages: 90-93, Published: FEB 2013
- Accession number :
- edsair.dedup.wf.001..dff633190d7fe2ca9b48aa9be5bca846