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Characterization and function of human Ly-6/uPAR molecules
- Source :
- BMB Reports, Vol 45, Iss 11, Pp 595-603 (2012)
- Publication Year :
- 2012
- Publisher :
- Korean Society for Biochemistry and Molecular Biology, 2012.
-
Abstract
- Human Ly-6/uPAR molecules are a superfamily composed oftwo subfamilies; one is the membrane bound proteins with aGPI-anchor and the other are secreted proteins without theGPI-anchor. Ly-6/uPAR molecules have remarkable amino acidhomology through a distinctive 8-10 cysteine-rich domain thatis associated predominantly with O-linked glycans. Thesemolecules are encoded by multiple tightly linked genes locatedon Chr. 8q23, and have a conserved genomic organization.Ly-6/uPAR molecules have an interesting expression patternduring hematopoiesis and on specific tumors indicating thatLy-6/uPAR molecules are associated with development of theimmune system and carcinogenesis. Thus, Ly-6/uPAR moleculesare useful antigens for diagnostic and therapeutic targets.This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well aswhat is known about their function in normal and malignanttissues and suggest Ly-6/uPAR molecules as target antigens forcancer immunotherapy.
- Subjects :
- Tumorigenesi
Cancer therapy
Cancer metastasis
biological factors
Hematopoiesis
lcsh:Biochemistry
enzymes and coenzymes (carbohydrates)
Immune system
lcsh:Biology (General)
lcsh:QD415-436
biological phenomena, cell phenomena, and immunity
skin and connective tissue diseases
neoplasms
Gene family
lcsh:QH301-705.5
Subjects
Details
- Language :
- English
- ISSN :
- 19766696
- Volume :
- 45
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- BMB Reports
- Accession number :
- edsair.doajarticles..1445dcf78b1fe7a98b72720aefe3c7bc