Design and synthesis of antituberculosis compounds

In view of the increasingly prominent drug resistance of tuberculosis(TB)drugs, the rational structure modification of antituberculosis drugs can improve the efficacy of TB treatment. In this paper, nine novel asymmetric substituted ureas were successfully prepared by reacting isoniazid(INH)with different isocyanates. This kind of urea bridge structure has inhibitory effect on cystine synthase in mycobacterium tuberculosis(MTB).The synthesized products were confirmed by mass spectrometry (MS)and nuclear magnetic resonance spectroscopy(1H NMR).