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Design and synthesis of antituberculosis compounds
- Source :
- Journal of Shanghai Normal University (Natural Sciences), Vol 49, Iss 4, Pp 416-421 (2020)
- Publication Year :
- 2020
- Publisher :
- Academic Journals Center of Shanghai Normal University, 2020.
-
Abstract
- In view of the increasingly prominent drug resistance of tuberculosis(TB)drugs, the rational structure modification of antituberculosis drugs can improve the efficacy of TB treatment. In this paper, nine novel asymmetric substituted ureas were successfully prepared by reacting isoniazid(INH)with different isocyanates. This kind of urea bridge structure has inhibitory effect on cystine synthase in mycobacterium tuberculosis(MTB).The synthesized products were confirmed by mass spectrometry (MS)and nuclear magnetic resonance spectroscopy(1H NMR).
- Subjects :
- Q1-390
cysteine synthase
Science (General)
synthesis
antituberculosis
urea bridge
Subjects
Details
- Language :
- English
- ISSN :
- 10005137
- Volume :
- 49
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of Shanghai Normal University (Natural Sciences)
- Accession number :
- edsair.doajarticles..335a7322d37f90ceb0468f8a3eab1d5d