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Advances in research on the regulation mechanism of hepcidin in sepsis related anemia

Authors :
Fu-Xing Li
Ke-Xin Xie
Yu-Lin Zhang
Wei-Dong Zhao
Source :
Medical Journal of Chinese People's Liberation Army, Vol 45, Iss 12, Pp 1299-1303 (2020)
Publication Year :
2020
Publisher :
Editorial Board of Medical Journal of Chinese People's Liberation Army, 2020.

Abstract

Sepsis remains an area of concern and focus of investigations in the medical community. The patients with sepsis often develop anemia, which may substantially increase the difficulty of treatment in septic patients. Hepcidin plays a crucial role in the regulation of iron homeostasis. Dysregulation of hepcidin has been implicated in the occurrence and development of several diseases. This review summarizes the characteristics of iron metabolism, the regulation of hepcidin and the key findings of the clinical studies targeting anemia in septic patients. Understanding underlying pathogenic mechanisms of hepcidin in sepsis-related anemia will contribute to the development of rational therapeutic strategies. DOI: 10.11855/j.issn.0577-7402.2020.12.15

Details

Language :
Chinese
ISSN :
05777402
Volume :
45
Issue :
12
Database :
OpenAIRE
Journal :
Medical Journal of Chinese People's Liberation Army
Accession number :
edsair.doajarticles..5eed5aa3a0931075c58fa97fa1efddf1