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Correlation of JMJD3 and Epithelial-mesenchymal Transition-related Protein Expression in Breast Cancer and Clinical Significance
- Source :
- Zhongliu Fangzhi Yanjiu, Vol 47, Iss 4, Pp 268-272 (2020)
- Publication Year :
- 2020
- Publisher :
- Magazine House of Cancer Research on Prevention and Treatment, 2020.
-
Abstract
- Objective To investigate the expression of histone demethylase JMJD3 and epithelial-mesenchymal transition (EMT) related proteins in breast cancer and their correlation. Methods Immunohistochemical SP method was used to detect the expression of JMJD3 and EMT-related proteins E-cadherin, Vimentin and N-cadherin in 120 cases of breast cancer and adjacent tissues. The correlation of JMJD3, EMT-related proteins with clinicopathological characteristics of breast cancer patients was analyzed. Results The positive rates of JMJD3 and E-cadherin in breast cancer tissues (56.67% and 65.00%) were significantly lower than those in adjacent tissues (73.33% and 83.33%) (P < 0.05). The positive rates of Vimentin and N-cadherin in breast cancer tissues (54.17% and 58.33%) were significantly higher than those in adjacent tissues (23.33% and 20.83%) (P < 0.05). The expression of JMJD3, E-cadherin Vimentin and N-cadherin were correlated with histological classification, TNM stage and lymph node metastasis of breast cancer. JMJD3 was correlated with tumor diameter (P < 0.05). Spearman correlation analysis showed that JMJD3 expression was positively correlated with E-cadherin expression in breast cancer (r=0.204, P=0.025), while JMJD3 was negatively correlated with Vimentin and N-cadherin expression (r=-0.467, r=-0.500, P=0.000). Conclusion JMJD3 may regulate the invasion and metastasis of breast cancer through regulating EMT.
Details
- Language :
- Chinese
- ISSN :
- 10008578
- Volume :
- 47
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Zhongliu Fangzhi Yanjiu
- Accession number :
- edsair.doajarticles..a203ffd03cd996a5b389c78b36fb78fc