Evaluation of Acute Phase Response in Blood and Milk Samples of Healthy Holstein Cattle in the Postpartum Period

Normally, birth triggers an acute phase response (APR). In particular, interleukins and proinfl ammatory cytokines released from activated leukocytes at the site of tissue damage stimulate APR. In the liver, these cytokines also stimulate acute phase proteins (APPs). APPs are one of the options used in monitoring the health status of animals. This study was evaluated in 12 healthy Holstein cattle, 3-6 years old, who calved at least once. Blood and milk samples were collected from the animals’ immediately after calving (0th h) and on the 7th, 14th, and 21st days postpartum. Haptoglobin (Hp), serum amyloid A (SAA), ceruloplasmin (Cp), milk amyloid A (MAA), albumin, total protein (TP) and globulin levels were determined in blood serum and milk serum samples. In the findings; when the measurements of blood and milk Hp, Cp and SAA and TP values were compared; there was a statistically significant diff erence (P