ХРОНИЧЕСКИЙ ВИРУСНЫЙ ГЕПАТИТ В: ВЗАИМОСВЯЗЬ ЭЛЕКТРИЧЕСКИХ И ВЯЗКОУПРУГИХ ХАРАКТЕРИСТИК ЭРИТРОЦИТОВ С ВИРУСНОЙ АКТИВНОСТЬЮ

The features of the electrical and viscoelastic parameters of red blood cells obtained by dielectrophoresis in patients with chronic hepatitis B in depending on the level of viral load were investigated. It has been found that the summerized rigidity, viscosity, conductivity, index of aggregation and destruction, the relative polarizability significantly increased and polarizability at all frequencies, the velocity of cells to the electrodes, electric capacitance of membranes — decreased as ascending viremia. A marked change in the parameters of red blood cells in patients with high viral load, likely, reflects the expressed degree of disadaptation of erythrocytes. Correlation of electrical and viscoelastic parameters erythrocytes with the biochemical indices reflecting the level of dysproteinemia, cytolysis, immune-inflammatory syndrome have been installed. The data obtained allow us to supplement understanding of the pathogenesis of systemic manifestations of virus hepatitis B and association of high viral load with a significant change in the viscoelastic and electrical properties of red blood cells.