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Fractal and Euclidean geometric diagnostic methodology of uterine cervix cells = Metodología diagnóstica geométrica fractal y euclidiana de células del cuello uterino
- Source :
- Iatreia, Vol 27, Iss 1, Pp 5-13 (2014)
- Publication Year :
- 2014
- Publisher :
- Universidad de Antioquia, 2014.
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Abstract
- Background: Pathological interpretation of cellular form in cervical cytology is very important for preven- tion of cervical cancer. The methods most frequently used for assessment of this test have reproducibility and inter-observer variability problems. Objective: To make fractal and Euclidean measure- ments to mathematically diagnose normal and pre- malignant cells of cervical squamous epithelium. Methodology: 21 cells with normal, ASCUS or LSIL diagnosis according to the Bethesda system were assessed. Fractal and Euclidean geometric measures of three mathematical objects were calculated: cyto- plasm, nucleus and whole cell. Mathematical propor- tions between these measurements were calculated in order to compare them with conventional classification methods. Results: It was found that the nuclear border measures calculated with the 2-pixel grill and the surface measures could mathematically and objectively differentiate normal cells from the pre-malignant ones (ASCUS and LSIL). Conclusions: An objective and reproducible diagnos- tic method was developed; it allows to identify the evolution towards malignant cellular states based on simultaneous fractal and Euclidean measures, estab- lishing the severity level of ASCUS and LSIL cells.
Details
- Language :
- Spanish; Castilian
- ISSN :
- 20117965 and 01210793
- Volume :
- 27
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Iatreia
- Accession number :
- edsair.doajarticles..ea216a90902b4db556f2c5e013b93846