Research progress on adenosine A2B receptor and its role in related diseases

Adenosine is an endogenous nucleoside that modulates many physiological processes. Adenosine is also a chemical mediator that regulates many physiological processes, including inflammation, ischemia and hypoxia. Its actions are mediated by interaction with specific cell membrane receptors. Four subtypes of adenosine receptors have been cloned: A1, A2A, A2B, and A3. Among there receptors, A2B receptor is one of the adenosine receptors with the lowest affinity with adenosine. In recent years, a large number of studies have shown that adenosine A2B receptor is involved in a variety of pathological and physiological processes of diseases. Herein, we try to review the recent advances made in the study of A2B receptor. DOI: 10.11855/j.issn.0577-7402.2019.12.13