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Monoclonal gammopathy of renal significance triggering atypical haemolytic uraemic syndrome
- Source :
- Nephrology. 22:15-17
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Haemolytic uraemic syndrome is a rare condition with an overall incidence of one to two cases in a population of 100 000 and approximately 10% of these cases are classified as atypical.[1] Atypical haemolytic uraemic syndrome (aHUS) is a thrombotic microangiopathy (TMA) characterized by microangiopathic haemolytic anaemia (MAHA), thrombocytopenia and acute kidney injury. aHUS can be genetic, acquired or idiopathic (negative genetic screening and no environmental triggers). We describe a case of aHUS triggered by monoclonal gammopathy of renal significance (MGRS) successfully treated with plasmapheresis and a bortezomib-based chemotherapy regimen, resulting in marked improvement in renal function and other markers of haemolysis. This patient has been in remission for more than 2 years currently.
- Subjects :
- education.field_of_study
Thrombotic microangiopathy
business.industry
medicine.medical_treatment
Population
030232 urology & nephrology
Acute kidney injury
Renal function
General Medicine
urologic and male genital diseases
Haemolysis
medicine.disease
Chemotherapy regimen
03 medical and health sciences
0302 clinical medicine
Nephrology
hemic and lymphatic diseases
Membranoproliferative glomerulonephritis
Immunology
medicine
Plasmapheresis
030212 general & internal medicine
education
business
Subjects
Details
- ISSN :
- 13205358
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Nephrology
- Accession number :
- edsair.doi...........0145ea3837d317936b502f26973c086c