An optimised in situ procedure for the oxazaborolidine catalysed enantioselective reduction of prochiral ketones

Authors :: N. N. Joshi
Kavirayani R. Prasad
Source :: Tetrahedron: Asymmetry. 7:3147-3152
Publication Year :: 1996
Publisher :: Elsevier BV, 1996.
Abstract: A systematic study was conducted to formulate the optimal reaction parameters for the oxazaborolidine catalysed enantioselective reduction. The catalyst derived from diphenyl prolinol was found to be the best amongst several other analogues and a reduction temperature of 45 °C is recommended for high enantioselectivity (92–99% ee ) for the reduction of alkyl aryl ketones.

Subjects :: In situ
chemistry.chemical_classification
Chemistry
Aryl
Organic Chemistry
Enantioselective synthesis
Catalysis
Prolinol
Inorganic Chemistry
Reduction (complexity)
chemistry.chemical_compound
Organic chemistry
Physical and Theoretical Chemistry
Alkyl

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