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Ce(IV) Doped TiO2 Nanoparticles and the Effect on Proliferation of BEL7402 Human Hepatoma Cells
- Source :
- Key Engineering Materials. :307-310
- Publication Year :
- 2007
- Publisher :
- Trans Tech Publications, Ltd., 2007.
-
Abstract
- To investigate nanoparticles’ antitumor effect, a globose 30~35nm Ce(IV) doped Titanium dioxide nanoparticles (CDT) were prepared by impregnation method and characterized by X-ray diffraction (XRD) and transmission electron microscopy(TEM). Proliferation of BEL7402 human Hepatoma cells was studied in vitro by using fluorescence microscopy and Flow Cytometry. The results show that cerium elements doping enhanced thermal stability of nano-size titanium dioxide to 800°C. With UV irradiated for 8min, BEL7402 were induced a dose-dependent apoptosis by CDT, about 28.2% , 41.5% and 88.3% cells were induced apoptosis after 24h at concentration of 60, 120 and 180ug/ml respectively, relative to 3.9% of that of control group cell just only in the presence of UV.
- Subjects :
- Materials science
medicine.diagnostic_test
Mechanical Engineering
technology, industry, and agriculture
Analytical chemistry
chemistry.chemical_element
Nanoparticle
Flow cytometry
Cerium
chemistry.chemical_compound
chemistry
Mechanics of Materials
Apoptosis
Transmission electron microscopy
Titanium dioxide
medicine
Fluorescence microscope
General Materials Science
Thermal stability
Nuclear chemistry
Subjects
Details
- ISSN :
- 16629795
- Database :
- OpenAIRE
- Journal :
- Key Engineering Materials
- Accession number :
- edsair.doi...........01a5651cb08d6146586ee1ca711dac4e