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Methylation scores for smoking, alcohol consumption, and body mass index and risk of seven types of cancer

Authors :
Gianluca Severi
Melissa C. Southey
Graham G. Giles
Allison M. Hodge
Ee Ming Wong
J. E. Joo
Chenglong Yu
Roger L. Milne
Dallas R. English
Chol-Hee Jung
Daniel F. Schmidt
Pierre Antoine Dugué
John L. Hopper
Enes Makalic
Daniel D. Buchanan
Publication Year :
2021
Publisher :
Cold Spring Harbor Laboratory, 2021.

Abstract

Methylation marks of exposure to health risk factors may be useful markers of cancer risk as they might better capture current and past exposures than questionnaires, and reflect different individual responses to exposure. We used data from seven case-control studies nested within the Melbourne Collaborative Cohort Study of blood DNA methylation and risk of colorectal, gastric, kidney, lung, prostate and urothelial cancer, and B-cell lymphoma (N cases=3,123). Methylation scores (MS) for smoking, body mass index (BMI), and alcohol consumption were calculated based on published data as weighted averages of methylation values. Rate ratios (RR) and 95% confidence intervals for association with cancer risk were estimated using conditional logistic regression and expressed per standard deviation increase of the MS, with and without adjustment for health-related confounders. The contribution of MS to discriminate cases from controls was evaluated using the area under the curve (AUC). After confounder adjustment, we observed: large associations (RR∼1.5-1.7) with lung cancer risk for smoking MS; moderate associations (RR∼1.2-1.3) with urothelial cancer risk for smoking MS and with mature B-cell neoplasm risk for BMI and alcohol MS; moderate to small associations (RR∼1.1-1.2) for BMI and alcohol MS with several cancer types and cancer overall. Generally small AUC increases were observed after inclusion of several MS in the same model (colorectal, gastric, kidney, urothelial cancers: +3%; lung cancer: +7%; B-cell neoplasms: +8%). Methylation scores for smoking, BMI, and alcohol consumption show independent associations with cancer risk, and may provide some improvements in risk prediction.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........01b498ce6dedd4db9d37a5d1c4ca168d
Full Text :
https://doi.org/10.1101/2021.02.08.21251370