Poly(ADP-Ribose)Polymerase and NMN Adenylyl-Transferase Interaction: Molecular and Immuno-Logical Studies

Despite the increasing interest on both the physiological and pathological role of ADP-ribosylation reactions, little appears to be known about the mechanism by which the intracellular level of NAD+ is regulated with respect to its participation in the redox metabolism on the one hand and to its utilization in poly(ADP-ribosy)lation on the other. Conditions enhancing poly(ADPribosyl)ation can significantly lower NAD+ concentration thereby influencing NAD+ dependent metabolic processes in the whole cell, while the cellular redox status can be signaled to chromatin thereby influencing the level of ADPribosylation of nuclear proteins (1).