Systematic analysis of fertility and clinical outcomes of assisted reproductive technology in Chinese patients with autosomal dominant polycystic kidney disease

This study attended to systematically analyze the patients’ fertility and clinical outcomes of ART who suffered with ADPKD. Methods: 61 couples who underwent PGT-M at our Centre from January 2015 to July 2021 were selected for retrospective analysis. Patients were divided into Group Aand B. Results: Our data showed the high-quality embryo rate of Group A was higher than that of Group B (70.1% vs.51.3%, PP > 0.05). The analysis of fertility-related data showed that there was no significant correlation by further comparing the ADPKD gene mutation sites, and no significant difference in the euploidy rate of embryos between Group A and B (66.7% vs. 72.6%, P > 0.05). Conclusion: The ADPKD gene was not significantly associated with patients' good-quality embryo rates. Although male patients who suffered from ADPKD showed a higher proportion of teratospermia and severe oligoasthenospermia,which resulted in a lower good embryo quality rate, the euploidy rate of embryos or clinical outcome of ART was not significantly affected.