ChemInform Abstract: Synthesis of Phosphinic Acid Analogues of Glycyl-Glycine and Crystal Structure of N-Glycyl-aminomethyl(phenylphosphinic) Acid

Phosphinic acid analogues of Gly-Gly, NH2CH2CONHCH2-P(R)O2H (R = Me, Ph, t-Bu), were synthesised by the active ester method from free aminomethylphosphinic acids purified on cation exchange resins. The crystal and molecular structure was determined for Gly–Gly(PPh)·H2O (R = Ph). The results point to similar bond parameters as were found for Gly–Gly and its phosphonic analogue Gly–Gly(P).