Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

Authors :: Tadashi Mishina
Kenji Chiba
Shigeo Sasaki
Tetsuro Fujita
Toshiyuki Kohara
Masafumi Arita
Kunitomo Adachi
Noriyoshi Nakao
Source :: Bioorganic & Medicinal Chemistry Letters. 5:853-856
Publication Year :: 1995
Publisher :: Elsevier BV, 1995.
Abstract: FTY720 (2-amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride), a novel synthetic immunosuppressant led by modification of ISP-I (myriocin, thermozymocidin) displayed potent immunosuppressive activity both in vitro and in vivo.

Subjects :: biology
Hydrochloride
Stereochemistry
Organic Chemistry
Clinical Biochemistry
Pharmaceutical Science
biology.organism_classification
Biochemistry
In vitro
chemistry.chemical_compound
chemistry
Design synthesis
In vivo
Myriocin
Drug Discovery
Isaria sinclairii
Molecular Medicine
Molecular Biology

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