Device-related thrombus formation in patients received one-stop intervention for nonvalvular atrial fibrillation：A systemic review and meta-analysis

Introduction：Combing CA and LAAO into one procedure has become a prospective measurement for patients with nonvalvular atrial fibrillation. Data on the incidence of DRT in one-stop intervention, treatment strategy, and its clinical implications are limited. Methods：A meta-analysis of observational studies evaluating the incidence, treatment strategy, and clinical implications of DRT was conducted. Results：Overall 21 studies describing DRT events and one case were included in the study. The pooled incidence of DRT in one-stop intervention was 1.2% (range from 0% to 7.3%, 95%CI 0.7%-1.8%, I2=0). 56.25% of events were diagnosed in the first three months after the procedure. All cases were diagnosed with a trans-esophagus echocardiogram (TEE). All patients diagnosed with DRT were prescribed anticoagulants. And 63% (12/19) events were reported with complete thrombus resolution. Anticoagulation duration varied greatly from 30d to 6m. Unknown clinical events were reported relating to DRT. Conclusions：DRT is an uncommon complication of the one-stop intervention. It occurs mainly in the first three months after the procedure. Anticoagulation seems to be an appropriate method for dissolving thrombus.