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Ph2S/selectfluor-promoted deoxydifluorination of aldehydes
- Source :
- Tetrahedron. 83:131963
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The installation of a HCF2 group is a research area that has received increasing attention, and deoxydifluorination of aldehydes have served as an attractive protocol due to the wide availability of aldehydes. Herein we describe a Ph2S/Selectfluor-promoted deoxydifluorination of aldehydes under mild conditions. Compared with previous deoxydifluorination methods, which usually use hazardous reagents such as SF4, DAST and Deoxo-Fluor, this protocol is quite attractive because of the safe and convenient operations, and the use of easily available reagents.
Details
- ISSN :
- 00404020
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Tetrahedron
- Accession number :
- edsair.doi...........036039ce6c8f01d118e417a20ea1ea68