Back to Search Start Over

Sex differences in the decline of neutralizing antibodies to SARS-CoV-2

Authors :
Yoann Madec
Aurélie Velay
Isabelle Staropoli
Hugo Mouquet
Olivier Schwartz
Floriane Gallais
Ludivine Grzelak
Marie-Josée Wendling
Samira Fafi-Kremer
Cyril Planchais
Yves Hansmann
Nicolas Meyer
Catherine Schmidt-Mutter
David Rey
María González
Arnaud Fontanet
Timothée Bruel
Ludovic Glady
Jérôme De Seze
Publication Year :
2020
Publisher :
Cold Spring Harbor Laboratory, 2020.

Abstract

The evolution of SARS-CoV-2 humoral response in infected individuals remains poorly characterized. Here, we performed a longitudinal study of sera from 308 RT-qPCR+ individuals with mild disease, collected at two time-points, up to 6 months post-onset of symptoms (POS). We performed two anti-S and one anti-N serology assays and quantified neutralizing antibodies (NAbs). At month 1 (M1), males, individuals > 50 years of age or with a body mass index (BMI) > 25 exhibited higher levels of antibodies. Antibody levels decreased over time. At M3-6, anti-S antibodies persisted in 99% of individuals while anti-N IgG were measurable in only 59% of individuals. The decline in anti-S and NAbs was faster in males than in females, independently of age and BMI. Our results show that some serology tests are less reliable overtime and suggest that the duration of protection after SARS-CoV-2 infection or vaccination will be different in women and men.

Details

Database :
OpenAIRE
Accession number :
edsair.doi...........0377875f79e4ded32f16219b07545536
Full Text :
https://doi.org/10.1101/2020.11.12.20230466