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Melanin-instructed biomimetic synthesis of copper sulfide for cancer phototheranostics
- Source :
- Chemical Engineering Journal. 388:124232
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Biomimetic synthesis is a promising strategy for the preparation of nanotheranostics with excellent biocompatibility. Herein, we report a biomimetic approach to synthesize folic acid (FA) modified copper sulfide (CuS) nanodots for cancer phototheranostics by using melanin as a biotemplate and FA as a stabilizer. Owing to the high affinity of melanin for metal ions, copper ions can be adsorbed on the surface of melanin and then reacted with S2− ions to form CuS nanodots. As a natural biomolecule, melanin has high biocompatibility and biodegradability, which can effectively improve the biosafety of the prepared CuS nanodots. More importantly, both melanin and CuS have strong near-infrared (NIR) absorption, the as-prepared CuS-Melanin-FA composite nanoprobes with high photothermal conversion efficiency are promising for augmented photoacoustic imaging and photothermal therapy of cancer, which is demonstrated on 4T1 tumor-bearing mice. Moreover, the biomimetic synthesis method for the preparation of CuS nanodots opens a new horizon for the biomimetic synthesis of other nanotheranostics.
- Subjects :
- chemistry.chemical_classification
Biocompatibility
General Chemical Engineering
Metal ions in aqueous solution
Biomolecule
Nanotechnology
02 engineering and technology
General Chemistry
Photothermal therapy
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Industrial and Manufacturing Engineering
0104 chemical sciences
Melanin
Copper sulfide
chemistry.chemical_compound
chemistry
Biomimetic synthesis
Environmental Chemistry
Nanodot
0210 nano-technology
Subjects
Details
- ISSN :
- 13858947
- Volume :
- 388
- Database :
- OpenAIRE
- Journal :
- Chemical Engineering Journal
- Accession number :
- edsair.doi...........0382a9c617bd0ee5e269a128552cae2f