P024 Disturbed sexual functioning in female patients with idiopathic inflammatory myopathies

Career situation of first and presenting author Student for a master or a PhD. Introduction Idiopathic inflammatory myopathies (IIM) are characterized by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which leads to functional impairment, reduced quality of life including sexual life. Objectives The aim of this study was to assess sexual functions/quality of life and pelvic floor function in female IIM patients compared to age-/sex-matched healthy controls (HC). Methods In total, 22 women with IIM [mean age: 55.1, disease duration: 7.9 years, dermatomyositis (DM, 8)/polymyositis (PM, 10)/necrotizing myopathy (IMNM, 3)/inclusion body myositis (IBM, 1)], who fulfilled the Bohan/Peter 1975 criteria for DM/PM, and 22 healthy controls (mean age: 55.1 years) filled in 12 well-established and validated questionnaires assessing sexual function and pelvic floor function, fatigue, physical activity and depression. We used the following questionnaires: Female Sexual Function Index (FSFI), Brief Index of Sexual Function for Women (BISF-W), Sexual Quality of Life Questionnaire (SQoL-F), Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire (PISQ-12), Pelvic Floor Distress Inventory Questionnaire (PFIQ7), Fatigue Impact Scale (FIS), Beck’s Depression Inventory II (BDI II), Health Assessment Questionnaire (HAQ) and Human Activity Profile (HAP). Results Compared to HC, patients with IIM had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W: in all subscales as well as total scores), dysfunction of pelvic floor (PISQ-12), and worse sexual quality of life (SQoL-F). Worse scores in IIM patients were associated with elevated muscle enzyme levels [lactate dehydrogenase: FSFI (r=−0.524, p=0.0123), BISFW (r=−0.528, p=0.0115)], greater fatigue [FIS: FSFI (r=−0.434, p=0.0438), BISF-W (r=−0.488, p=0.0211), SQoL-F (r=−0.488, p=0.0070), PISQ-12 (r=0.643, p=0.0013)], more severe depression [BDI-II: PISQ-12 (r=0.474, p=0,0258)], deteriorated quality of life [HAQ: PISQ-12 (r=0.476, p=0.0252)], and worse ability to perform physical activities [HAP: FSFI (r=0.437, p=0.0417), BISF-W (r=0.451, p=0.0351), PISQ-12 (r=−0.494,p=0.0195)]. Conclusions Women with IIM reported significantly disturbed sexual function, sexual quality of life and pelvic floor function than age-matched healthy controls. Worse scores in IIM were associated with disease activity, physical activity, fatigue, depression and quality of life. Acknowledgements Supported by AZV-16-33574A, MHCR 023728, and SVV – 2 60 373. Disclosure of Interest None declared.