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The Use of Very Low Calorie Diets in the Management of Type 2 Diabetes Mellitus
- Source :
- South African Journal of Clinical Nutrition. 29:96-102
- Publication Year :
- 2016
- Publisher :
- Informa UK Limited, 2016.
-
Abstract
- It was believed that Type 2 diabetes (DM2) was a progressive condition, with gradual decrease in beta-cell function. Data from the United Kingdom Prospective Study indicate that approximately only 50% beta-cell function remains at the time of diagnosis which decreases to 30% within 6 years. 1 This reduction in betacell function is associated with treatment intensification including additional oral hypoglycaemic agents and ultimately insulin. 1 Due to the decrease in beta-cell function, the first phase insulin response (insulin secretion within the first 10 minutes after eating) is believed to be permanently lost in people with Type 2 diabetes. 2,3 Lim et al. (2011) challenged this view when the first phase insulin secretion normalised following a very low calorie diet (VLCD) (less than 600 kcal) for 8 weeks. 4 Subsequently, glycaemic control normalized and DM2 was in remission. It is not surprising that this study led researchers to question if DM2 could be reversed 3 and sparked mass interest in these diets from people living with DM2. 5
- Subjects :
- medicine.medical_specialty
Nutrition and Dietetics
business.industry
Insulin
medicine.medical_treatment
food.diet
Treatment intensification
Medicine (miscellaneous)
Type 2 Diabetes Mellitus
030209 endocrinology & metabolism
Type 2 diabetes
medicine.disease
Very low calorie diet
03 medical and health sciences
0302 clinical medicine
Endocrinology
food
Internal medicine
Low calorie diet
Insulin response
medicine
030212 general & internal medicine
Prospective cohort study
business
Subjects
Details
- ISSN :
- 22211268 and 16070658
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- South African Journal of Clinical Nutrition
- Accession number :
- edsair.doi...........053d2410697e5bf65f9fcc6b77920cc1