DRESS SYNDROME: TREATMENT OF ORAL LESIONS WITH LASERTHERAPY

DRESS syndrome (drug rash with eosinophilia and systemic symptoms) or drug hypersensitivity syndrome, presents a prevalence of 2% to 3% among the in-hospital population. In the present case, patients admitted to the intensive care unit (ICU) after intracranial surgery presented generalized facial edema, maculopapular exanthema and scaly erythroderma. During intra-buccal inspection, multiple ulcerated lesions with bleeding were observed at the lowest stimulation on the lips and oral mucosa at various localization sites. Laboratory tests revealed eosinophilia, thrombocytopenia, leukocytosis, and elevation of TGO, TGP, and CPK levels. In view of the clinical picture, it was found to be DRESS syndrome. The treatment of oral lesions consisted of cleaning, crust removal, and low-intensity laser therapy with red light. After 10 sessions of laser therapy, ulcerated lesions were resolved. The patient was discharged and has been under follow-up for 7 months.