PD11-08 SINGLE CELL SEQUENCING REVEALS LUMINAL EPITHELIA PLASTICITY WITH FIBROBLAST ACTIVATION UPON SRD5A2 DELETION IN THE PROSTATE

INTRODUCTION AND OBJECTIVE:Steroid 5α reductase 2 (SRD5A2) is the predominant enzyme responsible for prostatic development and growth. SRD5A2 inhibitors are the only class of benign prostate hyperp...