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Asymmetric Chlorination of 4-Substituted Pyrazolones Catalyzed by Chiral Copper Complexes
- Source :
- Synlett. 31:1318-1322
- Publication Year :
- 2020
- Publisher :
- Georg Thieme Verlag KG, 2020.
-
Abstract
- A fast and highly enantioselective chlorination of 4-pyrazolones catalyzed by bis(oxazoline)–Cu(ClO4)2·6H2O complexes has been developed. Under the optimized conditions, a series of pyrazolones bearing stereogenic chlorine-attached carbon centers were obtained in moderate to high yields (up to 98%) and with enantioselectivities of up to 98% ee.
Details
- ISSN :
- 14372096 and 09365214
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Synlett
- Accession number :
- edsair.doi...........06abc6711e938e5fa28f0ccd35138847