ChemInform Abstract: Stereospecific Synthesis of a GS 4104 Metabolite: Determination of Absolute Stereochemistry and Influenza Neuraminidase Inhibitory Activity

Authors :: Choung U. Kim
David J. Sweeny
Paul A. Escarpe
Willard Lew
Dirk B. Mendel
Source :: ChemInform. 31
Publication Year :: 2010
Publisher :: Wiley, 2010.
Abstract: The total synthesis for the determination of the absolute stereochemistry of a GS 4104 metabolite 3 is described. In addition, the influenza neuraminidase inhibitory activity of 3 and related intermediates are reported.

Subjects :: chemistry.chemical_compound
Stereospecificity
biology
chemistry
Stereochemistry
Metabolite
biology.protein
Total synthesis
General Medicine
Inhibitory postsynaptic potential
Neuraminidase

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