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Multicomponent catalytic Mannich Reaction: a methodological study with lawsone

Multicomponent catalytic Mannich Reaction: a methodological study with lawsone

Authors :
Valdemar Lacerda
R. B. dos Santos
Rodolfo G. Fiorot
E. V. R. de Castro
J. F. Allochio Filho
S. G. Greco
Source :
Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings.
Publication Year :
2013
Publisher :
Editora Edgard Blücher, 2013.

Abstract

The multicomponent one-pot synthesis has received great importance due to its wide range of applications in pharmaceutical chemistry and combinatorial libraries for drug discovery. The Mannich reaction is a classical method for the preparation of -aminocarbonylated compounds from amine, aldehyde and an active CH bond, and it’s one of the most important reaction in organic chemistry. Our research group described the multicomponent Mannich reaction with lawsone and various aldehydes and amines in ethanol at room temperature, according to the procedure found in the literature with some modifications. It should be noticed that the reaction times ranged from 12 to 48 hours, depending on the aldehyde and the amine used. Dabiri and co-workers published Mannich reaction in aqueous medium, under reflux, using InCl3 as catalyst where reaction times varied from 4 to 7.5 hours.

Details

Database :
OpenAIRE
Journal :
Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings
Accession number :
edsair.doi...........07e08476406c4fbd8aa41548229f2d35
Full Text :
https://doi.org/10.5151/chempro-15bmos-bmos2013_2013915222817