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Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy
- Source :
- Pediatric Blood & Cancer. 57:454-460
- Publication Year :
- 2011
- Publisher :
- Wiley, 2011.
-
Abstract
- Background Neurocognitive impairment occurs in 20%-40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and homocysteine elevation following methotrexate treatment. We evaluated the relationship between folate pathway polymorphisms and neurocognitive impairment after childhood ALL chemotherapy.
- Subjects :
- Oncology
Genetics
Methotrexate treatment
medicine.medical_specialty
Chemotherapy
Childhood leukemia
Homocysteine
business.industry
medicine.medical_treatment
Hematology
medicine.disease
chemistry.chemical_compound
Leukemia
chemistry
hemic and lymphatic diseases
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
business
Childhood all
Childhood Acute Lymphoblastic Leukemia
Neurocognitive
Subjects
Details
- ISSN :
- 15455009
- Volume :
- 57
- Database :
- OpenAIRE
- Journal :
- Pediatric Blood & Cancer
- Accession number :
- edsair.doi...........08a062060a420a45dd0757f73e86c485
- Full Text :
- https://doi.org/10.1002/pbc.23162