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Fumaria densiflora DC. Alkaloids

Authors :
J. Sousek
Petr Sedmera
Ctirada Vavrečková
Eva Táborská
Vilím Šimánek
Hana Bochořáková
Source :
Collection of Czechoslovak Chemical Communications. 61:1064-1072
Publication Year :
1996
Publisher :
Institute of Organic Chemistry & Biochemistry, 1996.

Abstract

Twenty isoquinoline alkaloids were identified in the aerial part of Fumaria densiflora DC. In addition to bicuculline, densiflorine, fumaritine, fumariline, scoulerine, coptisine, cryptopine, parfumine, protopine, and sinactine which have been found previously, the following alkaloids were isolated for the first time from this species: adlumine, fumaricine, fumaritridine, fumarophycine, fumarofine, corytuberine, cis-N-methylstylopinium iodide, stylopine, and two new 1-benzylisoquinoline alkaloids, viz. fumaflorine and fumaflorine methyl ester. The cytoprotectivity of extracts of F. densiflora and F. officinalis, and that of protopine, cryptopine, and parfumine was tested on primary cultures of rat hepatocytes intoxicated with carbon tetrachloride. The cytoprotective effect of the extracts is associated with the alkaloids.

Details

ISSN :
12126950 and 00100765
Volume :
61
Database :
OpenAIRE
Journal :
Collection of Czechoslovak Chemical Communications
Accession number :
edsair.doi...........08bc2f8f5264125c7879a68a6ee756d2
Full Text :
https://doi.org/10.1135/cccc19961064