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A Novel Vpu Adaptive Mutation of HIV-1 Degrades Tetherin in Northern Pig-Tailed Macaques (Macaca leonina) Mainly via the Ubiquitin-Proteasome Pathway and Increases Viral Release
- Source :
- Journal of Virology. 97
- Publication Year :
- 2023
- Publisher :
- American Society for Microbiology, 2023.
-
Abstract
- HIV-1 has obvious host specificity, which has greatly hindered the construction of animal models and severely restricted the development of HIV-1 vaccines and drugs. To overcome this barrier, we attempted to isolate the virus from NPMs infected with stHIV-1sv, search for a strain with an adaptive mutation in NPMs, and develop a more appropriate nonhuman primate model of HIV-1.
- Subjects :
- Virology
Insect Science
Immunology
Microbiology
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi...........08dc1d26d86304771cb37e4604f22a42